Principles of the AACE/ACE Algorithm for Glycemic Control

Principles of the AACE/ACE Algorithm for Glycemic Control

• Early aggressive glucose control, the importance of which has been demonstrated by the DCCT/EDIC trial
• Targeting PPG excursions, particularly at lower A1c levels (where they comprise a significant component of the A1c)
• Stratified treatment protocols based on presenting A1c in drug naïve patients or A1c on treatment when not at goal
• Combination therapy early in the treatment paradigm initially at an A1c of 7.6%-9.0% or after 2 to 3 months of monotherapy at an A1c of 6.5%-7.5%
• Advancing therapy at 2- to 3-month intervals, addressing the problem of clinical inertia